Network pharmacology analysis of integration of dietary plant-derived natural flavonoids and gut microbiota for the treatment of Polycystic Ovary syndrome (PCOS) - PubMed
4 hours ago
- #PCOS
- #Gut Microbiota
- #Flavonoids
- Polycystic Ovary Syndrome (PCOS) is an endocrine disorder characterized by hyperandrogenism, ovulatory dysfunction, and metabolic dysregulation.
- The study explores the 'gut-diet' axis, focusing on the interaction between dietary flavonoids and gut microbiota for PCOS treatment.
- Key flavonoids identified are Luteolin and Quercetin, which interact with specific gut microbial taxa.
- Critical targets include AKT1, EGFR, and INSR, converging on the MAPK signaling pathway.
- The findings provide a theoretical framework for integrated PCOS management, suggesting future research should focus on experimental validation and clinical translation.