Dual-positive CTCs in patients with advanced breast cancer show metastatic potential and prognostic value - PubMed
12 hours ago
- #breast cancer
- #circulating tumor cells
- #prognostic biomarker
- Dual-positive circulating tumor cells (DPcells) in advanced breast cancer patients are associated with worse survival, especially in those with fewer than five CTCs.
- The prognostic value of DPcells varies by breast cancer subtype, being more significant in triple-negative and HER2-positive cases.
- Single-cell genomic profiling revealed genomic aberrations in 28% of DPcells and 93% of CTCs, indicating malignancy potential.
- DPcells were detected in immunocompetent but not immunodeficient mice, with no difference in metastatic colonization ability compared to control cancer cells.
- The study underscores the need for further research into DPcells as a prognostic biomarker and their role in metastasis formation.