Integrative analysis and experimental validation unveil TNFSF10 as a key PANoptosis inducer driving preeclampsia pathogenesis - PubMed
4 hours ago
- #Preeclampsia
- #PANoptosis
- #TNFSF10
- Preeclampsia is a life-threatening hypertensive disorder during pregnancy, posing risks to maternal and fetal health.
- PANoptosis, a newly identified inflammatory cell death pathway integrating apoptosis, necroptosis, and pyroptosis, is implicated in preeclampsia pathogenesis.
- TNFSF10 (tumor necrosis factor superfamily member 10) was identified as a key regulator of PANoptosis activation in preeclamptic placentas.
- Elevated expression of PANoptosis markers (cleaved caspase-3, cleaved caspase-7, cleaved caspase-1, p-MLKL) and GSDME pore formation were observed in preeclampsia placentas.
- TNFSF10 overexpression in trophoblast cells (HTR8/SVneo) induced PANoptosis, linking it to preeclampsia progression.
- TNFSF10-mediated PANoptosis promotes inflammation via NK cell activation and M1 macrophage polarization at the maternal-fetal interface.
- The study suggests TNFSF10 as a potential therapeutic target for preeclampsia by addressing both cell death and immune dysregulation.