A STING signaling relay from tumor cells to macrophages mediates the improved efficacy of combination chemotherapy in pancreatic cancer - PubMed
9 hours ago
- #Pancreatic Cancer
- #Chemotherapy
- #STING Pathway
- The study investigates the efficacy of adding cisplatin to the standard gemcitabine plus nab-paclitaxel (AG) regimen (AGP) for pancreatic ductal adenocarcinoma (PDAC) treatment.
- AGP regimen shows promising potential in both clinical retrospective analysis and PDAC mouse models.
- Cisplatin-induced DNA damage activates the tumor-intrinsic cGAS-STING pathway, enhancing CD8+ T cell recruitment and activation.
- Tumor-associated macrophages (TAMs) phagocytose tumor-derived molecules, triggering cGAS-STING signaling and promoting M1 polarization without significant macrophage death.
- A 'STING signaling relay' between tumor cells and TAMs reprograms the tumor microenvironment, improving chemotherapy efficacy.
- High STING expression in PDAC tissues correlates with increased cytotoxic T cells and M1-like macrophages, serving as an independent predictor of improved prognosis.
- The study highlights STING as a potential predictive biomarker and therapeutic target for PDAC.