Microglial NLRP3-dependent pyroptosis promotes cognitive dysfunction of diabetic encephalopathy by inhibiting adult hippocampal neurogenesis through the release of IL-1β - PubMed
4 hours ago
- #cognitive dysfunction
- #neuroinflammation
- #diabetic encephalopathy
- Diabetic encephalopathy (DE) leads to cognitive dysfunction with no current effective therapy.
- High glucose in DE impairs adult hippocampal neurogenesis (AHN) and induces microglial NLRP3-dependent pyroptosis.
- Microglial NLRP3 upregulation activates Gasdermin D (GSDMD) and caspase-1, leading to IL-1β release, which impairs AHN and cognitive function.
- Downregulation of microglial NLRP3 reduces pyroptosis, IL-1β release, improves AHN, and rescues cognitive deficits in DE models.
- Targeting microglial NLRP3 inflammasome-mediated pyroptosis may be a potential therapeutic strategy for DE.