Plasma proteomic signature of frailty in 50,506 adults - PubMed
3 hours ago
- #aging
- #proteomics
- #frailty
- Identified 1,339 plasma proteins significantly associated with frailty in 50,506 UK Biobank participants.
- Highlighted collagen-containing extracellular matrix and vesicle lumen pathways as key in frailty.
- Developed a proteomic frailty score (PFS) with strong predictive performance for 199 incident diseases.
- PFS showed responsiveness to 84 modifiable risk factors and accelerated progression with age.
- Observed biphasic pattern of frailty-associated proteomic dysregulation, peaking at ages ~50 and ~63.
- Created an online tool for public PFS calculation.