A transient receptor potential vanilloid 1-dependent corneal-trigeminal neuroinflammatory circuit promotes corneal neuropathy - PubMed
4 hours ago
- #corneal neuropathy
- #TRPV1
- #neuroinflammation
- TRPV1 channels' overactivation in dry eye leads to corneal neuropathy.
- Neuroinflammatory gene expression and macrophage reactivity occur in the trigeminal ganglion.
- Ocular surface macrophage activation and reduced corneal nerve density are observed.
- Substance P blockade can reverse TRPV1-driven corneal neurosensory abnormalities.
- The study suggests potential treatment targets for ocular surface disease-associated corneal neuropathy.