HSP70 preserves brain microvascular endothelial integrity under heat stress associated with suppressed JNK-mediated apoptosis and mitophagy - PubMed
4 days ago
- #Blood-Brain Barrier
- #Mitophagy
- #HSP70
- HSP70 helps maintain brain microvascular endothelial integrity during heat stress.
- Heat stress causes perivascular edema, oxidative injury, and mitochondrial damage in endothelial cells.
- Heat stress activates JNK signaling, leading to apoptosis and mitophagy.
- Autophagy and mitophagy contribute to endothelial cell injury under heat stress.
- HSP70 overexpression suppresses JNK activation, reducing oxidative damage and apoptosis.
- HSP70 interacts with JNK, offering a potential therapeutic target for heat stress-induced BBB dysfunction.