A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease-Like Non-Human Primate Model - PubMed
3 days ago
- #Alzheimer's disease
- #NeuroD1
- #neuroregeneration
- NeuroD1 AAV-based gene therapy tested in non-human primate (NHP) Alzheimer's disease (AD) model.
- Therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation.
- Repairs vascular and blood-brain barrier (BBB) damage, restores CSF AD biomarker levels.
- Improves hippocampal glucose metabolism and enhances spatial working memory.
- Transcriptome analysis shows upregulated neuronal function and synaptic transmission, downregulated neuroinflammation and apoptosis.
- Demonstrates potential for repairing and restoring brain structure and function in AD.