Microfluidic platforms for precision delivery of therapeutic cells in regenerative and personalized medicine - PubMed
4 hours ago
- #Cell Delivery
- #Microfluidics
- #Regenerative Medicine
- Microfluidic platforms address challenges in therapeutic cell delivery by enabling precise manipulation of fluids, biomaterials, and cells at microscale.
- They improve cell retention, engraftment, dose control, viability under shear, and allow site-specific placement and immunoisolation.
- These platforms mimic native tissue microenvironments and support scalable production of cell-laden carriers using advanced microfabrication techniques.
- Integration with CRISPR, synthetic biology, and sensors enables 'smart' therapeutic cells and real-time monitoring.
- Applications include stem cell purification, CAR-T cell manufacturing, and exosome-based delivery.
- Obstacles remain in regulatory standardization, large-scale manufacturing, and clinical workflow integration.