GID/CTLH E3 ligase complex control cell fate programs for sexual development of Plasmodium falciparum - PubMed
2 hours ago
- #malaria
- #E3 ligase
- #sexual development
- The PfGID E3 ubiquitin ligase complex regulates gametocyte development in Plasmodium falciparum by targeting key proteins for ubiquitination.
- Deletion of PfGID complex components leads to arrested gametocyte development and loss of transmission to mosquitoes.
- PfGID fine-tunes protein levels of two substrates: GD1, an RNA-binding protein, and PfDPL, a cryptochrome-like protein.
- PfDPL regulates the expression of male-specific proteins early in gametocyte development, essential for gametogenesis.
- GD1 holds transcripts crucial for gametocyte development in a state of translational repression.