Brg1 Interacts with LXR and H3K18la to Regulate Ferroptosis via the CYP4A14/20-HETE Axis in Liver Transplantation - PubMed
8 hours ago
- #liver transplantation
- #ferroptosis
- #Brg1
- Brg1 is upregulated after liver transplantation in both human and mouse grafts and correlates with liver injury.
- Brg1 knockout alleviates ischemia-reperfusion injury (IRI) and ferroptosis by suppressing CYP4A14 transcription and 20-HETE production.
- Brg1 interacts with LXR and histone modification H3K18la to promote CYP4A14 transcription, leading to 20-HETE synthesis from arachidonic acid.
- In vitro, Brg1 knockdown protects hepatocytes from injury and ferroptosis induced by oxygen-glucose deprivation/reperfusion (OGD/R), which is reversed by reintroducing CYP4A14 or 20-HETE.
- This study identifies Brg1 as a key regulator of IRI and ferroptosis in liver transplantation, offering a potential therapeutic target.