Targeting ferroptosis to halt MASLD and MASH - PubMed
4 hours ago
- #MASLD
- #ferroptosis
- #liver disease
- MASLD and MASH are significant liver diseases driven by ferroptosis, an iron-dependent programmed cell death.
- Key drivers of ferroptosis include dysregulated iron metabolism, increased peroxidation-susceptible phospholipids, and impaired antioxidant defenses.
- Ferroptosis promotes hepatocyte death through a 'ferroptotic explosion' involving FerroLipid, leading to fibrosis progression.
- Therapeutic strategies targeting ferroptosis include iron chelators and inhibitors to restore redox and lipid homeostasis.
- Systemic interactions between liver, adipose tissue, and gut microbiota influence ferroptotic susceptibility, offering new precision therapy opportunities.