Blood-based biomarker discovery for early pregnancy loss using integrative multi-omics strategies - PubMed
3 hours ago
- #early-pregnancy-loss
- #biomarkers
- #multi-omics
- Early pregnancy loss (EPL) is a major reproductive challenge with limited reliable blood-based biomarkers.
- An integrative multi-omics approach (proteomics and metabolomics) identified 26 proteins and 21 metabolites significantly altered in EPL.
- Functional analysis linked these biomarkers to immunoregulation and lipid oxidation processes in EPL pathogenesis.
- A diagnostic model combining ANGPTL4, PD-L1, neutrophil%, and lymphocyte% achieved high AUC values (up to 0.954) to distinguish EPL.
- The four-biomarker model validated well in an external cohort, showing promising predictive performance for EPL.
- Findings offer mechanistic insights and clinical translational value for early detection and management of EPL.