Analytical Review of Depression and Suicidality from Finasteride
5 hours ago
- #depression
- #suicidality
- #finasteride
- Finasteride, used for androgenetic alopecia, is linked to severe neuropsychiatric reactions like depression, anxiety, and suicidality, even after discontinuation.
- Evidence from multiple studies (2017-2023) shows a significant increase in depression and suicidal behavior risks with finasteride use.
- Delayed recognition of these risks over two decades may have led to widespread harm, including potential suicides.
- Manufacturers and regulators failed to conduct or request necessary pharmacovigilance studies, contributing to delayed risk awareness.
- Biological plausibility exists, as finasteride reduces neurosteroids like allopregnanolone, affecting mood regulation.
- Policy recommendations include halting finasteride marketing until safety is proven and enforcing post-approval surveillance studies.