Management of combined lacosamide and levetiracetam toxicity with intravenous 8.4% sodium bicarbonate and continuous renal replacement therapy - PubMed
9 hours ago
- #Epilepsy
- #Toxicology
- #Critical Care
- Combined toxicity of lacosamide and levetiracetam is rare.
- A patient with epilepsy ingested 8g lacosamide and 62.5g levetiracetam, leading to reduced consciousness and seizures.
- Initial ECG was normal but later showed QRS prolongation causing hemodynamic instability.
- Treatment included intravenous 8.4% sodium bicarbonate and continuous renal replacement therapy (CRRT).
- Patient's QRS duration normalized, seizures were controlled, and he made a full recovery.
- Early toxicology input, continuous ECG monitoring, and critical care are crucial for favorable outcomes.