Nuclear import of malaria RNA rewires splicing in host immune cells - PubMed
7 days ago
- #malaria
- #splicing-dysregulation
- #host-pathogen-interaction
- Malaria parasite Plasmodium falciparum manipulates host immune responses by interfering with host nuclear RNA processing.
- Malaria-encoded mRNAs evade degradation in host immune cells and are imported into host nuclei.
- Parasite transcripts bind host RNA-binding proteins ACIN1 and PNN, disrupting host splicing regulation.
- This interaction causes widespread misprocessing of host transcripts, altering immune function protein expression.
- The study reveals an RNA-based strategy where pathogen-derived transcripts exploit host splicing machinery to reshape immune signaling.