Single-cell analysis highlights the significance of malignant cell IFN/MHC-II for immunotherapy response in head and neck squamous cell carcinoma - PubMed
5 hours ago
- #single-cell RNA-seq
- #biomarker
- #immunotherapy
- Single-cell RNA sequencing on HNSCC patients before and after pembrolizumab treatment revealed an IFN/MHC-II expression program in malignant cells linked to immunotherapy response.
- Malignant cell MHC-II expression, validated at protein level and in a mouse model, correlates with sensitive tumors and favorable immune microenvironments.
- Pre-treatment malignant IFN/MHC-II serves as a biomarker for response, highlighting the crucial role of malignant cells in HNSCC immunotherapy.