African immigrants with type 2 diabetes present with three physiologic subtypes: implications for screening, diagnosis and treatment - PubMed
3 hours ago
- #Insulin Resistance
- #African Immigrants
- #Type 2 Diabetes
- African immigrants with type 2 diabetes (T2D) exhibit three physiologic subtypes: insulin-deficient (ID-T2D), insulin-resistant (IR-T2D), and combined insulin-deficient and insulin-resistant (ID+IR-T2D).
- ID-T2D was found in 45% of participants, IR-T2D in 30%, and ID+IR-T2D in 25%. ID+IR-T2D had the highest glucose levels, while IR-T2D showed the highest insulin levels.
- Phenotypic differences were noted: 20% of ID-T2D participants had a healthy weight, whereas all IR-T2D and ID+IR-T2D participants had central obesity and were overweight or obese.
- Sociodemographic factors like weight gain, sedentary lifestyle, and marriage rates increased across glucose tolerance categories but did not differ by T2D subtype.
- The study highlights the importance of addressing weight gain and lifestyle changes in T2D prevention and treatment for African immigrants and the broader population.