Sex and APOE genotype specific brain regional vulnerability to Alzheimer's Disease - PubMed
2 days ago
- #Alzheimer's Disease
- #APOE Genotype
- #Sex Differences
- Alzheimer's disease (AD) affects women and APOE4 carriers disproportionately.
- Study integrates diffusion MRI and blood transcriptomic data to explore sex and APOE interactions on white matter (WM) integrity.
- WM microstructure assessed via DTI and NODDI; regional vulnerability measured with a composite vulnerability score (CVS).
- Eve atlas brain parcellation identified common and sex-APOE group-specific affected regions (e.g., parahippocampal gyrus, cingulum).
- Gene co-expression network analysis linked blood expression data to group-specific WM vulnerability, revealing key gene subnetworks.
- Findings highlight how sex and APOE genotype jointly influence WM vulnerability and molecular signatures in AD.
- Insights may aid precision approaches in AD drug development, biomarker discovery, and clinical trial design.