Neurodevelopmental copy-number variants increase risk of internalizing and cardiometabolic multimorbidity: Findings from the UK Biobank - PubMed
3 hours ago
- #copy-number variants
- #neurodevelopmental genetics
- #multimorbidity risk
- ND-CNVs are linked to increased risk of internalizing and cardiometabolic multimorbidity (ICM-MM).
- ICM-MM combines internalizing conditions (e.g., depression, anxiety) with cardiometabolic diseases (e.g., hypertension, T2D).
- Female ND-CNV carriers show higher risk for internalizing conditions and type 2 diabetes.
- Deletion-type ND-CNVs, but not duplications, are associated with ICM-MM risk, linked to haploinsufficient genes.
- No interaction found between ND-CNVs and polygenic risk scores (PRSs) for ICM-MM.