ATGL sensitizes hepatocellular carcinoma cells to genotoxic drugs by modulating p53 acetylation/phosphorylation status - PubMed
4 hours ago
- #Genotoxic Drugs
- #ATGL
- #Hepatocellular Carcinoma
- ATGL enhances DNA damage in hepatocellular carcinoma (HCC) cells when exposed to genotoxic drugs like etoposide and doxorubicin.
- The mechanism involves ATGL activating PPARα/p300 signaling, leading to changes in p53 acetylation/phosphorylation status.
- This imbalance in p53 status promotes apoptotic cell death over cell cycle arrest and DNA repair.
- Bioinformatic analyses support a strong correlation between ATGL and PPARα/p300 signaling in HCC.
- High ATGL levels in HCC are associated with increased sensitivity to genotoxic drugs, suggesting ATGL as a predictive marker.
- Targeting ATGL or its downstream signaling could improve chemotherapy efficacy in HCC.