Immune cells regulate circulating adipocyte extracellular vesicle levels in response to metabolic shifts - PubMed
12 hours ago
- #immune cells
- #obesity
- #extracellular vesicles
- Extracellular vesicles (EVs) are key mediators of inter-organ signaling and linked to obesity and related diseases.
- New flow cytometry technologies enable study of adipocyte-derived EVs (adipoEVs) and their regulation.
- Tissue-resident immune cells, especially macrophages, clear EVs, influencing circulating EV levels.
- Obesity reduces EV uptake by adipose tissue immune cells, increasing circulating adipoEVs and decreasing clearance rates.
- Immune cells act as gatekeepers for tissue EV entry into circulation, regulating inter-organ EV signaling.