Characteristics and Prognosis of Early-Onset vs. Late-Onset Colon Cancer: A Propensity Score Matching Analysis Based on Histology - PubMed

8 hours ago

Study evaluates the influence of age at diagnosis and histologic subtype on colon cancer prognosis using SEER database data from 180,804 patients.
Patients were stratified into early-onset and late-onset groups, with histology types being adenocarcinoma or mucinous adenocarcinoma.
Early-onset colon cancer was associated with more advanced tumor stages.
Propensity score matching was used to balance cohorts for survival analyses (CSS and SSS).
Early-onset adenocarcinoma patients had the most favorable cancer-specific and surgery-specific survival.
Late-onset mucinous adenocarcinoma patients experienced the worst outcomes.
No significant age-related differences were found when stratified by histology.
Nonmetastatic early-onset adenocarcinoma showed significantly poorer surgery-specific survival compared to late-onset adenocarcinoma.
Findings highlight the need to integrate age and histologic type for accurate prognostic assessment and personalized treatment strategies.

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