Large-scale quantitative metabolomics and mass spectrometry imaging define the metabolic atlas in human acute type A aortic dissection - PubMed
3 hours ago
- #aortic dissection
- #metabolomics
- #mass spectrometry imaging
- Study uses large-scale targeted metabolomics to analyze metabolites in human ascending aorta from ATAAD, ATAA, and healthy donors.
- Quantitative profiling shows distinct hydrophilic metabolite and glycerophospholipid profiles in ATAAD, differing from ATAA and healthy controls.
- Altered metabolites in purine, pyrimidine, and amino acid pathways are specifically enriched in the tunica media and intima of ATAAD aorta.
- Hypoxanthine and pyroglutamic acid are identified as key ATAAD-altered metabolites; their circulating levels correlate with adverse outcomes in a prospective cohort.
- Functional studies confirm these metabolites promote aortic dissection by impairing vascular smooth muscle and endothelial cell functions.