Comparative safety of Potassium-competitive acid blockers on the risk of clostridium difficile infection: a multicenter cohort study - PubMed
4 hours ago
- #cohort study
- #acid suppressants
- #Clostridium difficile infection
- P-CABs showed no higher risk of Clostridium difficile infection compared to PPIs or H2RAs in a multicenter cohort study.
- Pooled hazard ratios were 0.87 for P-CABs vs PPIs, 0.85 for P-CABs vs H2RAs, and 1.13 for PPIs vs H2RAs, with confidence intervals crossing 1, indicating non-significant differences.
- Study used retrospective data from 15 hospitals, employing propensity score matching and meta-analysis across databases to compare acid-suppressive agents.
- Results remained consistent in subgroup and sensitivity analyses, supporting the comparative safety of P-CABs regarding CDI risk.