Myasthenia gravis and pregnancy: a systematic review and meta-analysis - PubMed
5 days ago
- #Myasthenia gravis
- #Pregnancy
- #Autoimmune disease
- Myasthenia gravis (MG) is an autoimmune disease that commonly affects women of reproductive age, potentially interfering with pregnancy.
- A systematic review and meta-analysis assessed the impact of pregnancy on MG, covering 34 studies and 3720 pregnancies.
- 30% of pregnancies reported worsening MG symptoms, most frequently in the first trimester.
- Postpartum exacerbations were observed in 27% of cases.
- Preterm birth occurred at a rate of 9%, with 68% vaginal deliveries and 32% cesarean sections.
- 9% of 1530 infants developed neonatal myasthenia gravis.
- Women with MG were more likely to require cesarean section or operative vaginal delivery compared to the general population.
- Study quality varied widely, indicating a need for prospective studies to better identify risk factors for complications.