DADA Enhances CD8+ T Cell Stemness to Improve Anti-Tumor Immunity and Immunotherapy Efficacy - PubMed
3 hours ago
- #metabolic reprogramming
- #CD8+ T cell
- #anti-tumor immunity
- DADA enhances CD8+ T cell stemness to improve anti-tumor immunity and immunotherapy efficacy.
- DADA promotes the accumulation of progenitor exhausted CD8+ T (Tpex) cells in the tumor microenvironment.
- Mechanistically, DADA increases oxidative phosphorylation (OXPHOS) and mitochondrial fitness by inhibiting pyruvate dehydrogenase kinase.
- DADA treatment improves the efficacy of PD-1 blockade in mice.
- DADA supplementation in CAR-T cell expansion enhances their stemness and anti-tumor efficacy.
- The study highlights DADA's potential in metabolic reprogramming for anti-tumor therapy.