Cell-Specific Roles of Angiopoietin-2 in CKD - PubMed
3 hours ago
- #Angiopoietin-2
- #CKD pathogenesis
- #Cell-specific roles
- Elevated kidney ANGPT2 mRNA in CKD patients correlates with lower estimated glomerular filtration rate, increased kidney fibrosis, and poorer kidney outcomes.
- Global deletion of angiopoietin-2 in mice preserves kidney function and reduces inflammation, vascular rarefaction, and fibrosis in experimental CKD, linked to suppressed pro-inflammatory and pro-fibrotic pathways and enhanced peroxisomal lipid metabolism.
- Endothelial cell-specific deletion of angiopoietin-2 attenuates early inflammatory signaling and endothelial activation but does not prevent late-stage vascular rarefaction and fibrosis in CKD.
- Tubular epithelial cell-specific deletion of angiopoietin-2 preserves kidney function and reduces fibrotic and vascular injury in late-stage CKD without affecting early inflammation, highlighting distinct cell-specific roles in pathogenesis.