CXCR5+ monocyte emigration impairs the radiation-induced antitumor immune response - PubMed
4 hours ago
- #immunosuppression
- #radioresistance
- #CXCR5+ monocytes
- CXCR5+ monocytes are enriched in tumors upon radiation, contributing to radioresistance.
- Tumor-derived VEGF induces CXCR5 expression on monocytes via the PI3K/mTOR/HIF-1α axis.
- Radiation enhances CXCL13 expression in tumor cells, recruiting CXCR5+ monocytes.
- CXCR5+ monocytes inhibit CD8+ T cells through PD-1/PD-L1 interaction, promoting radioresistance.
- Radiation-induced GM-CSF drives CXCR5+ monocytes to differentiate into M2-like macrophages.
- Blocking VEGFR, CXCL13, GM-CSF, or PD-L1 improves radiation-induced tumor control.
- Increased CXCR5+ and CD14+ populations are observed in cancer patients post-radiotherapy.
- Monocyte levels rise in peripheral blood of patients with progressive disease after radiotherapy.