Gasdermins against intracellular bacterial pathogens - PubMed
a day ago
- #Gasdermins
- #Pyroptosis
- #Intracellular Pathogens
- Gasdermins (GSDM) play a crucial role in host immune responses against intracellular bacterial pathogens by inducing pyroptosis.
- Pyroptosis is a lytic cell death mechanism caused by GSDM pore formation, eliminating intracellular niches and releasing cytokines.
- Five GSDM proteins (GSDMA-E) are activated by distinct signaling pathways to combat infections.
- Host-adapted pathogens like Shigella flexneri, Salmonella Typhimurium, and Mycobacterium tuberculosis can evade pyroptosis, unlike environmental pathogens such as Burkholderia thailandensis and Chromobacterium violaceum.
- Pyroptosis acts as a significant barrier against infection by environmental bacteria.