A germline-specific vesicular structure licenses mRNA activation during spermiogenesis and is hijacked in gastric cancer - PubMed
19 hours ago
- #Gastric Cancer
- #Autophagy
- #Spermiogenesis
- The MEX3D-HIP1 (MX-H) pathway and MEX3D-associated lysosomal vesicle (MXLV) govern mRNA activation during spermiogenesis by promoting ubiquitination of RBPs, triggering MXLV formation to degrade silent mRNP complexes.
- Genetic disruption of MX-H components in male germ cells leads to mRNP aggregate accumulation and male infertility, highlighting its role in spermiogenesis.
- The germline-restricted MXLV pathway is aberrantly activated in gastric cancer, where it promotes tumor progression, offering a potential therapeutic target with minimized effects on normal functions.