The Impact of Sex and Age on Antipsychotic Serum Concentrations - PubMed
4 hours ago
- #therapeutic drug monitoring
- #antipsychotic medication
- #menopause
- The study explores sex differences in serum concentrations of four antipsychotics: clozapine, olanzapine, aripiprazole, and quetiapine, and how these vary across age groups, including postmenopause (>55).
- Higher concentrations were found in women compared to men for clozapine and olanzapine, but not for quetiapine or aripiprazole.
- Young women (<45) showed higher levels of clozapine and olanzapine than men, but older women did not.
- Clozapine levels were higher in women <45 and 45-55 compared to women >55 years.
- For olanzapine, aripiprazole, and quetiapine, concentration differences between female age groups were absent.
- The findings suggest that monitoring antipsychotic levels may add clinical value and highlight the need for sex-specific prescription guidelines for olanzapine and clozapine.