ALG6 orchestrates coronavirus replication via the endoplasmic reticulum stress-autophagy axis - PubMed
3 hours ago
- #coronavirus replication
- #ALG6
- #ER stress-autophagy axis
- ALG6 is identified as an essential host factor for coronavirus (CoV) replication.
- ALG6's catalytic activity is crucial for transmissible gastroenteritis virus (TGEV) replication.
- ALG6 knockout (KO) inhibits viral entry by downregulating the receptor aminopeptidase N (ANPEP).
- ALG6 KO triggers endoplasmic reticulum (ER) stress, leading to suppressed viral replication.
- ER stress induced by ALG6 KO predominantly hinders viral replication by triggering downstream autophagy.
- ALG6 KO disrupts the formation of double-membrane vesicles (DMVs) during initial viral replication stages.
- The findings highlight ALG6's role in CoV replication, offering potential therapeutic strategies against future CoV infections.