Investigating the shared genetic architecture between inflammatory bowel disease and pancreatitis: a genome-wide cross-trait analysis - PubMed
4 hours ago
- #Immune pathways
- #Cross-trait analysis
- #Genetic architecture
- Study used Mendelian randomization to investigate causal relationships between inflammatory bowel disease (IBD) and pancreatitis, finding positive causal effects of ulcerative colitis on acute pancreatitis in Europeans and chronic pancreatitis in East Asians.
- Cross-trait meta-analysis identified 71 SNPs shared between IBD and pancreatitis, with MHC region SNPs enriched in dendritic cell differentiation and specific non-MHC SNPs linked to pancreatic exocrine enhancers and immune genes.
- Heritability enrichment and transcriptome-wide association studies indicated dendritic cells as a common cell type and SPINK5 in intestine as a pancreatitis-associated gene, highlighting shared genetic loci and immune pathways.