Clinical subtyping of severe acute pancreatitis reveals heterogeneous associations with early management strategies: a multicenter retrospective cohort study - PubMed
5 hours ago
- #Severe Acute Pancreatitis
- #Clinical Subphenotyping
- #Personalized Medicine
- Identified three stable clinical subphenotypes of severe acute pancreatitis (SAP): K1 (Stable type), K2 (Renal impairment-dominant type), and K3 (Elderly/Hepatic impairment type).
- K2 subphenotype had the highest in-hospital mortality (44.8%), with an adjusted hazard ratio of 6.70 for 28-day mortality compared to K1.
- Fluid overload (≥2.5L early) increased mortality specifically in K3, while low molecular weight heparin therapy benefited only K2 (aHR=0.66).
- An XGBoost classifier demonstrated high performance (macro-average AUC up to 0.997) for subphenotype identification.
- Phenotype-based management strategies could optimize SAP treatment, though findings require prospective validation.