Cell cycle dynamics regulate H3K27 and H3K9 histone modifications in Drosophila - PubMed
4 hours ago
- #Drosophila development
- #histone modifications
- #cell cycle
- Cell cycle dynamics influence histone modifications (H3K27ac, H3K27me3, H3K9me3) in Drosophila wing imaginal discs.
- Slower cell cycles increase H3K9me3 and H3K27me3 levels; faster cycles reduce them, while H3K27ac shows the opposite pattern.
- Changes affect genomic loci already modified in normal proliferation, not random new sites.
- Regulation involves a metabolically guided process, linking methylation rates to cell proliferation via metabolic activity, including Insulin/PI3K/Akt signaling.
- H3K27ac is controlled separately, with acetylation by CBP/Nejire peaking in S-phase and being reversed by HDAC1 after replication.