Neural APLNR Deficiency-Induced Anxiety-Like Behaviors Associate with the Alteration of Global Gene Expression - PubMed
5 hours ago
- #APLNR
- #anxiety
- #transcriptomics
- Neural APLNR deficiency in mice leads to anxiety-like behaviors.
- The study used neural cell-specific Aplnr knockout mice (Aplnr-cKOnestin) to avoid lethality issues.
- Transcriptomic profiling revealed significant gene dysregulation in the prefrontal cortex (PFC) and amygdala of Aplnr-cKOnestin mice.
- Dysregulated genes are involved in pathways like inflammatory response, immune response, and oxytocin signaling.
- Network analysis identified key hub genes in inflammatory and oxytocin signaling pathways.
- The findings suggest APLNR as a potential therapeutic target for anxiety disorders.