Tissue-Specific Differential Flux Analysis Reveals Metabolic Insights Into Pancreatic β-Cell Dysfunction in Type 2 Diabetes - PubMed
4 hours ago
- #drug repurposing
- #type 2 diabetes
- #metabolic modeling
- Study reconstructs genome-scale metabolic models for healthy and T2D pancreatic β-cells.
- Identifies disruptions in glucose metabolism and insulin biosynthesis in T2D β-cells.
- Finds reduced metabolic activity in amino sugar, amino acid, and peptide metabolism linked to diminished insulin production.
- Highlights reduced ubiquinone synthesis and enhanced fatty acid oxidation in T2D β-cells.
- Identifies biomarker genes associated with β-cell failure and potential drug targets.
- Drug repurposing analysis reveals 23 potential targets, with seven already linked to T2D treatment.
- Identifies 341 FDA-approved drugs as potential therapeutics for T2D.