Prompt and Intensive Antiviral Chemoprophylaxis in Nursing Home Influenza Outbreaks - PubMed
4 hours ago
- #Influenza Outbreaks
- #Nursing Homes
- #Antiviral Prophylaxis
- Study examines antiviral chemoprophylaxis with oseltamivir in nursing home influenza outbreaks.
- Goal: assess if starting prophylaxis for ≥70% of eligible residents within 2 days lowers mortality and hospitalization at 14 and 30 days.
- Retrospective cohort study of 404 outbreaks in 318 US nursing homes from 2018 to 2022, involving 35,086 resident-trial observations.
- Intensive prophylaxis (≥70% coverage) vs. non-intensive showed no significant difference in all-cause mortality at 14 or 30 days.
- Intensive prophylaxis significantly reduced hospitalizations at 14 days (risk ratio 0.79) with effects persisting less precisely at 30 days.
- Conclusion: prompt antiviral chemoprophylaxis for ≥70% of eligible residents within 2 days reduces hospitalization risk.