Visinin-like protein 1 disrupts calcium homeostasis and promotes atrial fibrillation in human and rodent models - PubMed
4 hours ago
- #Atrial Fibrillation
- #VILIP-1
- #Calcium Homeostasis
- Atrial fibrillation (AF) is linked to disturbed intracellular Ca2+ homeostasis.
- Visinin-like protein 1 (VILIP-1) is upregulated in AF patients and rodent models.
- VILIP-1 overexpression causes Ca2+ leakage, leading to delayed afterdepolarizations (DADs) and action potential duration alternans.
- VILIP-1 increases surface abundance of sodium-calcium exchanger 1 (NCX-1) via myristoylation-dependent trafficking.
- FDA-approved drugs repaglinide and desloratadine reduce NCX-1 surface expression and restore Ca2+ homeostasis.
- VILIP-1 is identified as a promising therapeutic target for AF.