Multifunctional Microneedle Patch with Antibacterial, Antioxidant, and Pro-Regenerative Properties for Scarless Wound Healing - PubMed
4 hours ago
- #scar prevention
- #microneedle patch
- #wound healing
- The study presents a multifunctional microneedle patch designed for scarless wound healing, targeting challenges like bacterial infection, oxidative stress, and inflammation.
- The patch has a core-shell structure: the shell uses melanin nanoparticles chelated with copper ions for antibacterial effects, while the core contains salvianolic acid B microparticles to reduce scar formation.
- In vitro tests showed the patch eliminates reactive oxygen species (ROS), inhibits bacterial growth, and promotes fibroblast migration and angiogenesis, with computational simulations confirming controlled drug diffusion.
- In vivo experiments on S. aureus-infected wounds demonstrated accelerated wound closure, reduced inflammation, and less scar formation, supported by histopathology and RNA sequencing that highlighted modulation of inflammatory and collagen pathways.