Retinal microvascular dysfunction in mild cognitive impairment: Associations with cerebral small vessel disease, plasma biomarkers, and cognitive decline - PubMed
3 hours ago
- #biomarkers
- #cognitive impairment
- #retinal microvasculature
- Retinal microvascular dysfunction is studied in mild cognitive impairment (MCI) patients.
- MCI patients showed greater retinal tortuosity and sparser vasculature compared to controls.
- These retinal changes correlated with higher PSMD, WMH volumes, and adverse plasma biomarkers.
- Mediation analysis indicated PSMD and WMH volumes partially mediated the association between retinal changes and cognitive decline.
- Findings suggest retinal microvascular dysfunction reflects cerebral small vessel disease and neurodegeneration in MCI.
- The study supports retinal imaging as a potential non-invasive biomarker for early cognitive decline.