Comparative efficacy and safety of liraglutide versus metformin, naltrexone/bupropion, and phentermine-topiramate in psychiatric patients - PubMed
4 hours ago
- #weight loss
- #liraglutide
- #psychiatric disorders
- Psychiatric patients have a high risk of obesity, often due to psychotropic medication-induced weight gain.
- Liraglutide (LIRA) showed greater short-term weight reduction compared to metformin (MET) in psychiatric outpatients.
- Female sex and full-time employment were associated with less weight loss, while the number of psychotropic medications showed a trend toward greater weight reduction.
- No significant differences in adverse events (AEs) were observed across the antiobesity medications (AOMs).
- Early discontinuation (ED) rates varied by drug type, being lowest for MET (39.1%) and highest for phentermine-topiramate (PT) (72.2%).
- Liraglutide may be a safe and effective weight-management option for psychiatric patients, but larger, long-term studies are needed for confirmation.