Astrocytic glucose metabolism regulates the survival of newborn hippocampal neurons in the adult brain - PubMed
6 hours ago
- #hippocampal neurons
- #astrocyte metabolism
- #adult neurogenesis
- Astrocytic glucose metabolism is crucial for the survival of newborn hippocampal neurons in the adult brain.
- Newborn neurons have slow intracellular glucose recovery and low glycolysis-related gene expression.
- Astrocytes show rapid decreases in glucose during exploration, followed by quick recovery, and produce lactate.
- Disrupting astrocytic glucose uptake, lactate production, or transport impairs activity-dependent neuron survival.
- The findings highlight an astrocyte-to-neuron metabolic pathway involving lactate, relevant to aging and disease.