SIRT3 deficiency impairs mitochondrial bioenergetics via hyperacetylation of TCA cycle enzymes in chronic heart failure - PubMed
2 days ago
- #Mitochondrial dysfunction
- #Protein acetylation
- #Chronic heart failure
- SIRT3 deficiency leads to impaired mitochondrial bioenergetics in chronic heart failure.
- Hyperacetylation of TCA cycle enzymes is a key mechanism in this impairment.
- Animal studies were approved by the Institutional Animal Care and Use Committee of Chongqing Medical University.
- One author has conflicts of interest related to TargTex S.A. and other affiliations, while others declare no conflicts.
- References include studies on heart failure incidence, global epidemiology, and mitochondrial TCA cycle metabolites.