Barrier organ mechanomedicine and therapeutic insights - PubMed
4 hours ago
- #mechanotransduction
- #barrier organs
- #therapeutic targets
- Mechanical forces like stretch, shear, and stiffness regulate development, homeostasis, and repair in barrier organs such as skin, lung, and cornea.
- Dysregulated mechanotransduction through pathways like Piezo1, TRPV4, and integrin-YAP drives fibrosis, inflammation, and impaired repair in these organs.
- Targeting these mechanosensitive circuits with small molecules, biologics, or stiffness-tuned biomaterials offers novel cross-organ therapies.
- Advancement in mechanosensitive pathways and biomaterials toward clinical testing requires an integrated cross-organ perspective for treating chronic barrier diseases.