Dengue virus harnesses mosquito Syntenin to load and secrete viral RNA into salivary exosomes - PubMed
4 hours ago
- #exosomes
- #mosquito-borne diseases
- #viral dissemination
- Dengue virus uses mosquito Syntenin (AeSyntenin) to load and secrete viral RNA into salivary exosomes.
- Subgenomic flaviviral RNA (sfRNA) promotes the secretion of sfRNA-containing EVs marked by AeSyntenin.
- SfRNA interacts with AeSyntenin via its stem loop structures, maintaining this interaction within EVs.
- Mosquito AeSyntenin plays a functional role in exosome production and salivary secretion of sfRNA.
- The study proposes a mechanism where sfRNA binds AeSyntenin for selective packaging and release into exosomes.