Quercetin ameliorates PCOS ovarian fibrosis by modulating short-chain fatty acid synthesis via increased akkermansia muciniphila abundance - PubMed
3 hours ago
- #PCOS
- #Quercetin
- #Ovarian Fibrosis
- Quercetin was tested at low, medium, and high doses in a PCOS mouse model, with the medium dose identified as optimal for restoring estrous cycles and improving insulin sensitivity.
- The study found that quercetin alleviated ovarian fibrosis, increased Akkermansia muciniphila abundance in the gut microbiota, and boosted short-chain fatty acid (SCFA) production, particularly acetate.
- Quercetin improved intestinal mucosal structure and barrier function in PCOS mice, enhancing the expression of tight junction proteins ZO-1 and Occludin.
- In vitro experiments using DHT-induced KGN cells showed that acetic acid, a SCFA, reduced TGF-β1 expression by inhibiting SMAD3 phosphorylation and promoting SMAD7 expression.
- The research suggests quercetin's mechanism for ameliorating PCOS ovarian fibrosis involves modulating gut microbiota and SCFA synthesis, offering a novel therapeutic approach.