Lipid accumulation product index, serum inflammatory cytokines, and dementia in rural older adults: A population-based study - PubMed
7 hours ago
- #inflammation
- #lipid metabolism
- #dementia
- The study investigates the association between the Lipid Accumulation Product (LAP) index and dementia in rural older adults in China.
- LAP index is calculated differently for men and women based on waist circumference and triglyceride levels.
- The research involved 5,670 participants, with 305 diagnosed with dementia (194 Alzheimer's disease (AD), 100 vascular dementia (VaD)).
- Higher LAP index was significantly associated with increased odds of all-cause dementia and AD, but not significantly with VaD.
- The highest quintile of LAP index showed stronger associations with dementia and AD compared to the lowest quintile.
- A significant correlation was found between higher LAP index and elevated serum inflammatory cytokines.
- The study suggests chronic systemic inflammation as a potential biological pathway linking high LAP index to dementia and AD.